|
KMID : 0525720140190040308
|
|
Journal of Chitin and Chitosan
2014 Volume.19 No. 4 p.308 ~ p.314
|
|
|
Fabrication and Application of Chitosan-Tripolyphosphate Nanoparticles
|
|
Lee Eun-Sung
Park Sang-Jun
Jang Ju-Woong
Shim Young-Bock
Kim Chun-Ho
|
|
|
Abstract
|
|
|
|
For the past few decades, several polymeric nanoparticles using natural polymers have been studied extensively for medical applications. Among the natural polymers, chitosan has been used in drug delivery system as nanoparticles because of biodegradable, biocompatible, and low toxicity. The positively charged amino groups in chitosan could perform the stable nanoparticles with anionic materials via electrostatic interaction. Here, we introduce various parameters for controlled size and zetapotential of chitosan-tripolyphosphate (TPP) nanoparticles such as concentration, molecular weight, pH of chitosan, concentration of TPP, reaction time and temperature in ionotropic gelation. The objectives of this review are to study the preparation methods and characteristics of chitosan-TPP nanoparticles, and finally to investigate their potential applications in drug delivery system.
|
|
|
KEYWORD
|
|
|
Chitosan, Tripolyphosphate, Nanoparticles, Drug delivery system
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|